Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 1.00 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10268092 | 0.89 | KARS1 (1.00) | KARS1SYKCSNK2A1MEN1NPC1 | |
| SCHEMBL901741 | 0.85 | KARS1 (0.74) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL1755683 | 0.82 | KARS1 (1.00) | KARS1SYKCSNK2A1NPC1RAB9A | |
| SCHEMBL902772 | 0.82 | KARS1 (1.00) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL902781 | 0.81 | KARS1 (1.00) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL902728 | 0.80 | KARS1 (1.00) | KARS1CAMK2DSYKMEN1NPC1 | |
| SCHEMBL1755624 | 0.78 | KARS1 (0.79) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL901943 | 0.78 | KARS1 (0.69) | KARS1CAMK2DSYKMEN1NPC1 | |
| SCHEMBL902707 | 0.77 | SYK (0.76) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL901241 | 0.77 | KARS1 (1.00) | KARS1SYKMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |