Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.76 |
| ▸ | KARS1 | Q15046 | 12/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.46 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.46 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755624 | 0.85 | KARS1 (0.79) | SYKKARS1MEN1NPC1KMT2A | |
| SCHEMBL902672 | 0.85 | KARS1 (0.74) | SYKKARS1MEN1NPC1KMT2A | |
| SCHEMBL1704457 | 0.82 | ITK (0.55) | SYKKARS1IGF1RKDR | |
| SCHEMBL902728 | 0.82 | KARS1 (1.00) | SYKKARS1MEN1NPC1KMT2A | |
| SCHEMBL902695 | 0.82 | KARS1 (0.60) | SYKKARS1MAP4K4 | |
| SCHEMBL10268092 | 0.79 | KARS1 (1.00) | SYKKARS1MEN1NPC1KMT2A | |
| SCHEMBL901241 | 0.79 | KARS1 (1.00) | SYKKARS1MEN1NPC1KMT2A | |
| SCHEMBL901240 | 0.79 | KARS1 (0.68) | SYKKARS1MAP4K4ABL1LCK | |
| SCHEMBL902781 | 0.79 | KARS1 (1.00) | SYKKARS1MEN1NPC1KMT2A | |
| SCHEMBL4903188 | 0.78 | KARS1 (0.64) | SYKKARS1MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |