Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.79 |
| ▸ | SYK | P43405 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.47 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.47 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902728 | 0.88 | KARS1 (1.00) | KARS1SYKMEN1KMT2ANPC1 | |
| SCHEMBL902672 | 0.86 | KARS1 (0.74) | KARS1SYKMEN1KMT2ANPC1 | |
| SCHEMBL902707 | 0.85 | SYK (0.76) | KARS1SYKMEN1KMT2ANPC1 | |
| SCHEMBL10268092 | 0.83 | KARS1 (1.00) | KARS1SYKMEN1KMT2ANPC1 | |
| SCHEMBL1755668 | 0.83 | KARS1 (0.60) | KARS1KDR | |
| SCHEMBL902781 | 0.82 | KARS1 (1.00) | KARS1SYKMEN1KMT2AKDM4E | |
| SCHEMBL10268299 | 0.81 | KARS1 (0.70) | KARS1SYKMEN1KMT2AKDM4E | |
| SCHEMBL901655 | 0.81 | KARS1 (0.70) | KARS1SYKMEN1KMT2AKDM4E | |
| SCHEMBL1755683 | 0.81 | KARS1 (1.00) | KARS1SYKNPC1RAB9AMAP4K4 | |
| SCHEMBL901241 | 0.80 | KARS1 (1.00) | KARS1SYKMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |