Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10268805 | 0.86 | KARS1 (0.69) | KARS1TAAR1 | |
| SCHEMBL901844 | 0.85 | KARS1 (0.52) | KARS1ROCK2ROCK1SLC5A1 | |
| SCHEMBL902772 | 0.82 | KARS1 (1.00) | KARS1KDRTAAR1SYK | |
| SCHEMBL1704269 | 0.81 | KARS1 (0.47) | KARS1ROCK2ROCK1KDRSLC5A1 | |
| SCHEMBL902820 | 0.79 | KARS1 (0.74) | KARS1SYK | |
| SCHEMBL902073 | 0.77 | KARS1 (0.71) | KARS1TAAR1SYK | |
| SCHEMBL902681 | 0.76 | KARS1 (0.70) | KARS1KDR | |
| SCHEMBL902781 | 0.73 | KARS1 (1.00) | KARS1KDRSYK | |
| SCHEMBL26985792 | 0.72 | TAAR1 (0.67) | TAAR1 | |
| SCHEMBL1704696 | 0.72 | KARS1 (0.67) | KARS1KDRTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |