Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.67 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.41 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902772 | 0.80 | KARS1 (1.00) | KARS1GSK3AGSK3BHTR7IGF1R | |
| SCHEMBL902681 | 0.76 | KARS1 (0.70) | KARS1KDRFYNBTKSRC | |
| SCHEMBL902289 | 0.76 | ITK (0.54) | KARS1ITKGSK3AGSK3BAURKA | |
| SCHEMBL902820 | 0.75 | KARS1 (0.74) | KARS1HTR7 | |
| SCHEMBL1704457 | 0.73 | ITK (0.55) | KARS1ITKAURKAAURKBIGF1R | |
| SCHEMBL902073 | 0.73 | KARS1 (0.71) | KARS1AURKATAAR1 | |
| SCHEMBL1704064 | 0.72 | KARS1 (0.69) | KARS1KDRTAAR1 | |
| SCHEMBL1704501 | 0.71 | HTR2C (0.45) | KARS1ITKGSK3AGSK3BAURKA | |
| SCHEMBL1704207 | 0.71 | KARS1 (0.66) | KARS1ITKHTR7AURKAAURKB | |
| SCHEMBL902609 | 0.70 | HTR2C (0.44) | KARS1ITKGSK3AGSK3BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |