Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9994891 | 0.86 | ALDH1A1 (0.66) | RAB9ANPC1HPGDPOLBALDH1A1 | |
| SCHEMBL8448713 | 0.83 | HPGD (0.49) | RAB9ANPC1HPGDALDH1A1DDX3X | |
| SCHEMBL28661809 | 0.82 | HSD17B10 (0.54) | RAB9ANPC1HPGDPOLBALDH1A1 | |
| SCHEMBL3380172 | 0.79 | POLB (0.60) | RAB9ANPC1HPGDPOLBALDH1A1 | |
| SCHEMBL665339 | 0.79 | RAB9A (0.75) | RAB9ANPC1HPGDPOLBALDH1A1 | |
| SCHEMBL3825402 | 0.78 | HTT (0.47) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL15286152 | 0.78 | MAPT (0.46) | RAB9ANPC1HPGDALDH1A1MEN1 | |
| SCHEMBL2085952 | 0.78 | TAS2R14 (0.43) | RAB9ANPC1HPGDPOLBALDH1A1 | |
| SCHEMBL2284014 | 0.78 | SMN1; SMN2 (0.58) | RAB9AHPGDPOLBALDH1A1HDAC3 | |
| SCHEMBL1006923 | 0.78 | LCK (0.45) | RAB9ANPC1POLBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558069-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| EP-2440245-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | Novartis AG (CH) | 2012-04-18 | — | — | EP | disclosed |
| WO-2011130379-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-20 | — | — | WO | disclosed |
| WO-2010144734-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | NOVARTIS AG (CH) | 2010-12-16 | — | — | WO | disclosed |
| CN-101304989-A | Carbocyclic fused cyclic amines as inhibitors of the coagulation factor XA | HOFFMANN LA ROCHE (CH) | 2008-11-12 | — | — | CN | disclosed |