Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.54 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901693 | 0.90 | KARS1 (0.68) | KARS1MAP3K12SYK | |
| SCHEMBL902955 | 0.87 | KARS1 (0.66) | KARS1MAP3K12SYK | |
| SCHEMBL901892 | 0.84 | KARS1 (0.58) | KARS1CARM1PRMT6PRMT8MAP3K12 | |
| SCHEMBL902780 | 0.81 | KARS1 (0.78) | KARS1CARM1PRMT6PRMT8PHGDH | |
| SCHEMBL902758 | 0.74 | KARS1 (0.64) | KARS1SYK | |
| SCHEMBL901944 | 0.74 | KARS1 (0.75) | KARS1MAP3K12SYK | |
| SCHEMBL901929 | 0.73 | KARS1 (0.55) | KARS1MAP3K12SYK | |
| SCHEMBL1705214 | 0.72 | KARS1 (0.73) | KARS1MAP3K12SYK | |
| SCHEMBL901891 | 0.72 | KARS1 (0.73) | KARS1PHGDHSYK | |
| SCHEMBL902272 | 0.71 | SYK (0.53) | KARS1MAP3K12SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |