Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.75 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705214 | 0.95 | KARS1 (0.73) | KARS1SYKMAP3K12 | |
| SCHEMBL901892 | 0.89 | KARS1 (0.58) | KARS1SYKCDK2CCNE1MAP3K12 | |
| SCHEMBL1704662 | 0.86 | KARS1 (0.72) | KARS1SYKCDK2CDK1SMG1 | |
| SCHEMBL1705137 | 0.85 | KARS1 (1.00) | KARS1SYKCDK2CDK1SMG1 | |
| SCHEMBL901693 | 0.84 | KARS1 (0.68) | KARS1SYKCDK2CDK1SMG1 | |
| SCHEMBL1704434 | 0.83 | KARS1 (0.68) | KARS1SYKCDK2CDK1SMG1 | |
| SCHEMBL1704952 | 0.82 | KARS1 (1.00) | KARS1SYKCDK2CDK1SMG1 | |
| SCHEMBL901824 | 0.81 | KARS1 (1.00) | KARS1 | |
| SCHEMBL902955 | 0.81 | KARS1 (0.66) | KARS1SYKMAP3K12 | |
| SCHEMBL901697 | 0.79 | KARS1 (0.65) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |