Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | KARS1 | Q15046 | 12/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902839 | 0.89 | SYK (0.60) | SYKKARS1MAP3K12 | |
| SCHEMBL1705310 | 0.88 | KARS1 (0.48) | SYKKARS1WNT3A | |
| SCHEMBL901929 | 0.88 | KARS1 (0.55) | SYKKARS1MAP3K12 | |
| SCHEMBL1705277 | 0.85 | JAK2 (0.44) | SYKWNT3A | |
| SCHEMBL13136098 | 0.84 | SYK (0.51) | SYKKARS1MAP3K12 | |
| SCHEMBL901697 | 0.83 | KARS1 (0.65) | SYKKARS1 | |
| SCHEMBL1704197 | 0.81 | KARS1 (0.49) | SYKKARS1WNT3A | |
| SCHEMBL901674 | 0.80 | KARS1 (0.62) | SYKKARS1 | |
| SCHEMBL901734 | 0.79 | HTT (0.46) | — | |
| SCHEMBL1704379 | 0.78 | KARS1 (0.62) | KARS1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |