Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 6/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185179 | 0.73 | RYR2 (0.36) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL31146716 | 0.73 | RYR2 (0.36) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL3894929 | 0.73 | RYR2 (0.36) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL17185647 | 0.73 | RYR2 (0.36) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL29463396 | 0.73 | MAOA (0.40) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL11217635 | 0.73 | MAOA (0.40) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL6969929 | 0.73 | RYR2 (0.40) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL19674181 | 0.73 | RYR2 (0.40) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL11118465 | 0.73 | RYR2 (0.40) | RYR2SIGMAR1HSD17B3MAOAMAOB | |
| SCHEMBL1486666 | 0.72 | RYR2 (0.33) | RYR2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2912037-A1 | 2-AMINOPYRIDINE COMPOUNDS | Merck Patent GmbH (DE) | 2015-09-02 | — | — | EP | disclosed |