Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11905601 | 1.00 | USP25 (0.41) | USP25CHRNB2CHRNA4HDAC1KDM1A | |
| SCHEMBL1668485 | 0.87 | CHRNB2 (0.43) | USP25CHRNB2CHRNA4KDM1AKHK | |
| SCHEMBL17056646 | 0.83 | CCR2 (0.36) | — | |
| SCHEMBL2461899 | 0.82 | HDAC1 (0.38) | HDAC1 | |
| SCHEMBL1668496 | 0.78 | CCR2 (0.39) | — | |
| SCHEMBL2461916 | 0.77 | CCR2 (0.38) | HDAC1 | |
| SCHEMBL2459768 | 0.77 | MAPT (0.41) | USP25HDAC1KHK | |
| SCHEMBL2463515 | 0.77 | MAPT (0.41) | USP25HDAC1KHK | |
| SCHEMBL2459776 | 0.77 | MAPT (0.41) | USP25HDAC1KHK | |
| SCHEMBL2461995 | 0.76 | ADRB1 (0.38) | USP25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488520-B1 | CONDENSED AZINE-DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME (NL) | 2015-09-02 | — | — | EP | disclosed |