Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901704 | 0.87 | CKS1B (0.48) | KARS1 | |
| SCHEMBL901702 | 0.85 | KARS1 (0.51) | KARS1 | |
| SCHEMBL901245 | 0.78 | KARS1 (0.52) | KARS1 | |
| SCHEMBL901708 | 0.78 | KARS1 (0.66) | KARS1 | |
| SCHEMBL901846 | 0.76 | KARS1 (0.46) | KARS1 | |
| SCHEMBL902751 | 0.76 | CKS1B (0.47) | KARS1 | |
| SCHEMBL902855 | 0.76 | KARS1 (0.40) | KARS1 | |
| SCHEMBL1705250 | 0.76 | ACHE (0.47) | — | |
| SCHEMBL901860 | 0.75 | KARS1 (0.46) | KARS1 | |
| SCHEMBL901949 | 0.75 | KARS1 (0.48) | KARS1KMT2ASMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |