Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 9/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901796 | 0.82 | KARS1 (0.45) | KARS1SYKMAP3K12 | |
| SCHEMBL22425334 | 0.77 | CHRNB2 (0.53) | — | |
| SCHEMBL10268986 | 0.76 | KARS1 (0.75) | KARS1SYK | |
| SCHEMBL902051 | 0.73 | KARS1 (0.55) | KARS1SYKMAP3K12 | |
| SCHEMBL902768 | 0.70 | KARS1 (0.52) | KARS1SYKCLK2GSK3BWNT1 | |
| SCHEMBL1704236 | 0.70 | KARS1 (0.52) | KARS1SYKCLK2GSK3BWNT1 | |
| SCHEMBL1704276 | 0.70 | KARS1 (0.68) | KARS1CLK2GSK3BWNT1CLK3 | |
| SCHEMBL901888 | 0.70 | KARS1 (0.68) | KARS1MAP3K12CLK2GSK3BWNT1 | |
| SCHEMBL1755607 | 0.70 | KARS1 (0.56) | KARS1MAP3K12CLK2GSK3BWNT1 | |
| SCHEMBL11963534 | 0.70 | KHK (0.42) | CLK2GSK3BWNT1CLK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |