Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 10/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704236 | 1.00 | KARS1 (0.52) | KARS1BRAFSYKIDH2WNT1 | |
| SCHEMBL1704640 | 0.91 | KARS1 (0.56) | KARS1BRAFSYKIDH2WNT1 | |
| SCHEMBL901888 | 0.88 | KARS1 (0.68) | KARS1BRAFWNT1CLK2CLK3 | |
| SCHEMBL1705099 | 0.83 | KARS1 (0.47) | KARS1SYKIDH2 | |
| SCHEMBL902491 | 0.82 | KARS1 (0.76) | KARS1SYKIDH2 | |
| SCHEMBL1704871 | 0.81 | KARS1 (0.44) | KARS1SYKIDH2 | |
| SCHEMBL1704276 | 0.80 | KARS1 (0.68) | KARS1BRAFWNT1CLK2CLK3 | |
| SCHEMBL901867 | 0.79 | KARS1 (0.53) | KARS1BRAFSYKIDH2 | |
| SCHEMBL901719 | 0.77 | SYK (0.41) | KARS1BRAFSYK | |
| SCHEMBL902653 | 0.73 | KARS1 (0.80) | KARS1BRAFSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |