Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 12/20 | 0.65 |
| ▸ | SCN10A | Q9Y5Y9 | 12/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PTPRC | P08575 | 2/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15901791 | 0.84 | SCN8A (0.65) | SCN8ASCN10A | |
| SCHEMBL15902052 | 0.83 | SCN8A (0.69) | SCN8ASCN10AJAK2JAK1TYK2 | |
| SCHEMBL28850189 | 0.82 | KCNK3 (0.60) | SCN8ASCN10APTPRCJAK2JAK1 | |
| SCHEMBL15907037 | 0.82 | SCN10A (0.55) | SCN8ASCN10A | |
| SCHEMBL15901597 | 0.82 | SCN8A (0.68) | SCN8ASCN10A | |
| SCHEMBL15907036 | 0.82 | SCN10A (0.58) | SCN8ASCN10A | |
| SCHEMBL28064012 | 0.81 | SCN8A (0.67) | SCN8ASCN10AMAPT | |
| SCHEMBL15901746 | 0.80 | SCN8A (0.65) | SCN8ASCN10AJAK2JAK1TYK2 | |
| SCHEMBL15901652 | 0.80 | SCN10A (0.69) | SCN8ASCN10A | |
| SCHEMBL15901646 | 0.80 | SCN10A (0.72) | SCN8ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164457-A | Pyridine keto-amide as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-105026373-B | Pyridone amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-03-30 | — | — | CN | disclosed |
| US-9393235-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150246028-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246028-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | SCN8A 77/4885SCN10A 12/4885MEN1 2606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.