Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 16/20 | 0.67 |
| ▸ | SCN10A | Q9Y5Y9 | 16/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28063993 | 0.82 | SCN8A (0.69) | SCN8ASCN10A | |
| SCHEMBL28064011 | 0.82 | SCN8A (0.69) | SCN8ASCN10A | |
| SCHEMBL17045005 | 0.81 | SCN8A (0.65) | SCN8ASCN10AMAPT | |
| SCHEMBL28063990 | 0.81 | SCN8A (0.67) | SCN8ASCN10AHTTTP53MAPT | |
| SCHEMBL28827905 | 0.81 | SCN8A (0.70) | SCN8ASCN10A | |
| SCHEMBL15561698 | 0.81 | SCN8A (1.00) | SCN8ASCN10A | |
| SCHEMBL28827910 | 0.80 | SCN8A (0.74) | SCN8ASCN10A | |
| SCHEMBL15901791 | 0.78 | SCN8A (0.65) | SCN8ASCN10A | |
| SCHEMBL29970845 | 0.77 | CHRNB2 (0.78) | HTTTP53MAPT | |
| SCHEMBL29201497 | 0.77 | CHRNB2 (0.78) | HTTTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473554-A | Fused piperidine amides as modulators of ion channels | VERTEX PHARMA | 2016-04-06 | — | — | CN | disclosed |