Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15550551 | 1.00 | APP (0.46) | APPCYP2C9HRH3ENPP2HPGDS | |
| SCHEMBL11029299 | 0.88 | HRH3 (0.46) | HRH3ENPP2HPGDSKCNH2MAPK1 | |
| SCHEMBL18532945 | 0.88 | HRH3 (0.46) | HRH3ENPP2HPGDSKCNH2MAPK1 | |
| SCHEMBL11942496 | 0.88 | HRH3 (0.46) | HRH3ENPP2HPGDSKCNH2MAPK1 | |
| SCHEMBL15551565 | 0.87 | EPHX2 (0.48) | APPCYP2C9HRH3ENPP2HPGDS | |
| SCHEMBL15551563 | 0.87 | EPHX2 (0.48) | APPCYP2C9HRH3ENPP2HPGDS | |
| SCHEMBL17053655 | 0.83 | HRH3 (0.55) | HRH3MAPK1SMN1; SMN2F2PLG | |
| SCHEMBL20325744 | 0.83 | HRH3 (0.53) | HRH3SMN1; SMN2F2PLGPLAU | |
| SCHEMBL17057724 | 0.81 | ENPP2 (0.52) | APPCYP2C9ENPP2KDM2BCYP2A6 | |
| SCHEMBL20171548 | 0.81 | ENPP2 (0.52) | APPCYP2C9ENPP2KDM2BCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877185-B1 | 2-(1-(1-(6-((CYCLOHEXYL)OXY)-5-(TRIFLUOROMETHYL)NAPHTHALEN-2-YL)ETHYL)PIPERIDIN-3-YL)ACETIC ACID DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATIONS AND AUTOIMMUNE DISORDERS | BIOGEN MA INC (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-2877185-B1 | 2-(1-(1-(6-((CYCLOHEXYL)OXY)-5-(TRIFLUOROMETHYL)NAPHTHALEN-2-YL)ETHYL)PIPERIDIN-3-YL)ACETIC ACID DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATIONS AND AUTOIMMUNE DISORDERS | BIOGEN MA INC (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9555050-B2 | ATX modulating agents | BIOGEN MA INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150246063-A1 | ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246063-A1 | ATX MODULATING AGENTS | ENPP2, ATXN10, ATXN2 | APP 2121/4885CYP2C9 4872/4885HRH3 2002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.