Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.48 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704302 | 0.91 | KARS1 (0.55) | KARS1SYKTGFBR1 | |
| SCHEMBL1704350 | 0.91 | KARS1 (0.47) | KARS1SYKTGFBR1 | |
| SCHEMBL1704534 | 0.91 | KARS1 (0.52) | KARS1SYKKDM4E | |
| SCHEMBL1704625 | 0.88 | KARS1 (0.61) | KARS1SYK | |
| SCHEMBL1704426 | 0.86 | KARS1 (0.63) | KARS1KDM4E | |
| SCHEMBL902995 | 0.83 | KARS1 (0.67) | KARS1SYK | |
| SCHEMBL1705215 | 0.82 | KARS1 (0.62) | KARS1SYK | |
| SCHEMBL902811 | 0.82 | KARS1 (0.51) | KARS1 | |
| SCHEMBL901995 | 0.81 | KARS1 (0.60) | KARS1 | |
| SCHEMBL1704340 | 0.81 | KARS1 (0.64) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |