Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.56 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902661 | 0.93 | KARS1 (0.68) | KARS1SCN9A | |
| SCHEMBL1704377 | 0.92 | KARS1 (0.54) | KARS1CYP3A4CYP2D6CYP2C9GRIN2B | |
| SCHEMBL901935 | 0.83 | KARS1 (0.65) | KARS1FAAHALDH1A1 | |
| SCHEMBL901421 | 0.82 | KARS1 (0.82) | KARS1FAAHMAPK10 | |
| SCHEMBL901966 | 0.81 | KARS1 (0.61) | KARS1 | |
| SCHEMBL901757 | 0.81 | KARS1 (0.66) | KARS1 | |
| SCHEMBL901834 | 0.81 | KARS1 (0.82) | KARS1 | |
| SCHEMBL901431 | 0.81 | KARS1 (0.60) | KARS1FAAH | |
| SCHEMBL1704868 | 0.81 | KARS1 (0.55) | KARS1CYP3A4CYP2D6CYP2C9GRIN2B | |
| SCHEMBL1704693 | 0.81 | KARS1 (0.59) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |