Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17048875 | 0.81 | GPR35 (0.36) | TSHRHTTALDH1A1MAPTKMT2A | |
| SCHEMBL17048849 | 0.78 | ALDH1A1 (0.31) | TSHRALDH1A1 | |
| SCHEMBL17048832 | 0.77 | — | — | |
| SCHEMBL17048826 | 0.76 | HSP90AA1 (0.38) | TSHRHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL17048896 | 0.75 | USP7 (0.33) | HTTALDH1A1MAPK1 | |
| SCHEMBL17048821 | 0.74 | ALDH1A1 (0.39) | HSD17B10TSHRHTTTRPV1NPC1 | |
| SCHEMBL17048714 | 0.67 | MAPT (0.39) | HTTNPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL17048815 | 0.67 | TDP1 (0.33) | — | |
| SCHEMBL17048831 | 0.65 | — | — | |
| SCHEMBL22749806 | 0.65 | GSR (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3110810-A1 | PYRAZOLE AMIDE DERIVATIVE | Teijin Pharma Limited (JP) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015129926-A1 | PYRAZOLE AMIDE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2015-09-03 | — | — | WO | disclosed |