Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26835590 | 0.78 | ADRA2A (0.52) | PTGS1THRBNPC1RAB9AMAPT | |
| SCHEMBL12365106 | 0.77 | BCL2L1 (0.46) | CYP2C9CYP2C19MAPTALDH1A1CYP3A4 | |
| SCHEMBL21294306 | 0.76 | MAPT (0.36) | THRBMAPTADRA2ACYP3A4 | |
| SCHEMBL30574503 | 0.76 | MAPT (0.36) | THRBMAPTADRA2ACYP3A4 | |
| SCHEMBL903245 | 0.75 | MAPT (0.46) | PTGS1THRBMEN1KMT2ANPC1 | |
| SCHEMBL30574504 | 0.73 | GPR3 (0.40) | MEN1KMT2ANPC1CYP1A2CYP2C9 | |
| SCHEMBL12365101 | 0.73 | PTGS1 (0.43) | PTGS1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2259569 | 0.71 | SLC9A1 (0.41) | CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL17049538 | 0.70 | MEN1 (0.39) | PDCD1CD274PTGS1THRBMEN1 | |
| SCHEMBL11192414 | 0.67 | MAOB (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120764-B2 | Chromene derivatives | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2015-09-01 | — | — | US | disclosed |