Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | USP2 | O75604 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806435 | 0.95 | USP2 (0.49) | ALDH1A1USP2L3MBTL1LMNANPSR1 | |
| SCHEMBL794476 | 0.76 | HCAR3 (0.47) | ALDH1A1LMNATSHRKMT2AMEN1 | |
| SCHEMBL30839246 | 0.76 | HCAR3 (0.47) | ALDH1A1L3MBTL1LMNATSHRNPC1 | |
| SCHEMBL29175771 | 0.76 | HCAR3 (0.47) | ALDH1A1L3MBTL1LMNATSHRNPC1 | |
| SCHEMBL27164238 | 0.76 | HCAR3 (0.39) | ALDH1A1USP2LMNAKMT2APOLB | |
| SCHEMBL8253693 | 0.75 | USP2 (0.59) | ALDH1A1USP2L3MBTL1LMNANPSR1 | |
| SCHEMBL13875589 | 0.75 | USP2 (0.63) | ALDH1A1USP2L3MBTL1LMNANPSR1 | |
| SCHEMBL5633033 | 0.74 | USP2 (0.58) | ALDH1A1USP2L3MBTL1LMNANPSR1 | |
| SCHEMBL23070283 | 0.74 | LMNA (0.39) | ALDH1A1USP2LMNANPSR1TSHR | |
| SCHEMBL29152989 | 0.73 | USP2 (0.66) | ALDH1A1USP2L3MBTL1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017112853-A1 | METHODS OF TREATING PULMONARY DISEASES AND DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2017-06-29 | — | — | WO | disclosed |
| WO-2015131080-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2015-09-03 | — | — | WO | disclosed |