Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | FAAH | O00519 | 1/20 | 0.64 |
| ▸ | TNF | P01375 | 1/20 | 0.61 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.61 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.61 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.60 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GPR183 | P32249 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617972 | 0.85 | ALDH1A1 (0.68) | FAAHTNIKMEN1KMT2AGPR183 | |
| SCHEMBL17054965 | 0.84 | NPC1 (0.73) | NPC1TNFNOD2NOD1PRKAA2 | |
| SCHEMBL17066302 | 0.83 | NPC1 (0.62) | NPC1FAAHTNFNOD2NOD1 | |
| SCHEMBL5184503 | 0.81 | KMT2A (0.75) | NPC1MEN1KMT2ARAB9AHTT | |
| SCHEMBL17054971 | 0.78 | NPC1 (0.62) | NPC1TNFNOD2NOD1PRKAA2 | |
| SCHEMBL3602903 | 0.78 | FAAH (1.00) | FAAH | |
| SCHEMBL31505240 | 0.78 | NPC1 (0.65) | NPC1TNFNOD2NOD1TNIK | |
| SCHEMBL31520459 | 0.78 | NPC1 (0.65) | NPC1TNFNOD2NOD1TNIK | |
| SCHEMBL31520460 | 0.78 | NPC1 (0.65) | NPC1TNFNOD2NOD1TNIK | |
| SCHEMBL24024134 | 0.78 | NPC1 (0.70) | NPC1FAAHTNFNOD2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9125904-B1 | Biphenyl imidazoles and related compounds useful for treating HCV infections | ACHILLION PHARMACEUTICALS, INC. (US) | 2015-09-08 | — | — | US | disclosed |