Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171047 | 0.95 | HTR1B (0.49) | ALDH1A1KDM4EHTR1BL3MBTL4L3MBTL3 | |
| SCHEMBL171049 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KDM4EHTR1BSMN1; SMN2GAA | |
| SCHEMBL165584 | 0.76 | RAF1 (0.42) | ALDH1A1KDM4EHTR1BSMN1; SMN2LMNA | |
| SCHEMBL13602320 | 0.76 | CYP1A2 (0.47) | ALDH1A1KDM4EHTR1BSMN1; SMN2LMNA | |
| SCHEMBL22138644 | 0.75 | ALDH1A1 (0.45) | ALDH1A1KDM4ESMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL19828150 | 0.75 | L3MBTL4 (0.65) | ALDH1A1KDM4EL3MBTL4L3MBTL3SMN1; SMN2 | |
| SCHEMBL13602319 | 0.74 | KDM4E (0.53) | ALDH1A1KDM4EHTR1BSMN1; SMN2HRH1 | |
| SCHEMBL21595803 | 0.72 | KDM4E (0.56) | ALDH1A1KDM4EHTR1BSMN1; SMN2LMNA | |
| SCHEMBL8003240 | 0.72 | MAPT (0.59) | ALDH1A1KDM4EL3MBTL4L3MBTL3SMN1; SMN2 | |
| SCHEMBL13602317 | 0.71 | KDM4E (0.53) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |