Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28480830 | 0.64 | CYP2C19 (0.30) | — | |
| SCHEMBL3624905 | 0.64 | GRM2 (0.32) | — | |
| SCHEMBL21380220 | 0.63 | DGAT1 (0.38) | — | |
| SCHEMBL11939899 | 0.63 | ARG1 (0.45) | CYP1A2 | |
| SCHEMBL4612910 | 0.63 | GRM2 (0.32) | — | |
| SCHEMBL30927134 | 0.63 | ARG1 (0.45) | CYP1A2 | |
| SCHEMBL1015563 | 0.63 | — | — | |
| SCHEMBL3725259 | 0.63 | EPHX1 (0.30) | — | |
| SCHEMBL12949893 | 0.63 | ARG1 (0.45) | CYP1A2 | |
| Bicarbonate SCHEMBL11288924 | 0.61 | MAPK1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440558-A1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144486-A1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |