Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058160 | 0.90 | MAPT (0.46) | POLBSMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11944411 | 0.84 | MAPT (0.40) | POLBALDH1A1NPBWR1MCHR1MAPT | |
| SCHEMBL11943855 | 0.83 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1HPGDL3MBTL1LMNA | |
| SCHEMBL17058437 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1NPBWR1MCHR1PKM | |
| SCHEMBL17058293 | 0.81 | HPGDS (0.42) | SMN1; SMN2ALDH1A1LMNAPKMMAPT | |
| SCHEMBL17058164 | 0.80 | ALDH1A1 (0.38) | POLBSMN1; SMN2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL11943853 | 0.80 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1PKMMAPTKMT2A | |
| SCHEMBL11943858 | 0.80 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1NPBWR1MCHR1HTT | |
| SCHEMBL17058335 | 0.80 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1PKMMAPTKMT2A | |
| SCHEMBL11943861 | 0.79 | ALDH1A1 (0.37) | POLBSMN1; SMN2ALDH1A1NPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |