Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ME2 | P23368 | 2/20 | 0.39 |
| ▸ | ME1 | P48163 | 2/20 | 0.39 |
| ▸ | ME3 | Q16798 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943855 | 0.91 | ALDH1A1 (0.41) | MAPTPKMALOX12ALDH1A1SMN1; SMN2 | |
| SCHEMBL17057930 | 0.90 | POLB (0.45) | MAPTPKMALOX12ALDH1A1SMN1; SMN2 | |
| SCHEMBL17058335 | 0.87 | ALDH1A1 (0.48) | MAPTPKMALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL11943853 | 0.86 | ALDH1A1 (0.49) | MAPTPKMALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL11943858 | 0.86 | ALDH1A1 (0.40) | MAPTPKMALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL17058164 | 0.85 | ALDH1A1 (0.38) | MAPTPKMALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11943857 | 0.84 | ALDH1A1 (0.44) | PKMALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL17058437 | 0.84 | ALDH1A1 (0.40) | MAPTPKMALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL17058188 | 0.84 | NPC1 (0.39) | MAPTPKMALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11943820 | 0.83 | HTR1A (0.39) | MAPTALDH1A1LMNAHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |