Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057909 | 0.87 | SCN9A (0.38) | SCN9ASCN10ASLC2A1SLC2A2SLC2A3 | |
| SCHEMBL11945066 | 0.84 | ALDH1A1 (0.49) | SCN9ASCN10AHSD17B10KDM4EGLA | |
| SCHEMBL11945064 | 0.84 | KDM4E (0.55) | SCN9ASCN10AHSD17B10KDM4EGLA | |
| SCHEMBL17058134 | 0.83 | SLC2A1 (0.37) | SCN9ASCN10ASLC2A1SLC2A2SLC2A3 | |
| SCHEMBL17058161 | 0.82 | SCN9A (0.38) | SCN9ASCN10ASLC2A1SLC2A2SLC2A3 | |
| SCHEMBL17058020 | 0.82 | GRM2 (0.38) | SCN9ASCN10ASLC2A1SLC2A2SLC2A3 | |
| SCHEMBL11945063 | 0.81 | HSD17B10 (0.44) | SCN9ASCN10AHSD17B10KDM4EGLA | |
| SCHEMBL17058435 | 0.81 | SLC2A1 (0.35) | SCN9ASCN10ASLC2A1SLC2A2SLC2A3 | |
| SCHEMBL17058375 | 0.79 | ALDH1A1 (0.39) | SLC2A1SLC2A3ALDH1A1 | |
| SCHEMBL11943942 | 0.79 | TSHR (0.49) | SCN9AHSD17B10KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |