Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.38 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058443 | 0.90 | DCTPP1 (0.37) | ALDH1A1DCTPP1RXFP1SMN1; SMN2SLC2A1 | |
| SCHEMBL17058056 | 0.88 | SMN1; SMN2 (0.37) | ALDH1A1DCTPP1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058556 | 0.88 | SMN1; SMN2 (0.37) | ALDH1A1DCTPP1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058551 | 0.87 | SMN1; SMN2 (0.35) | ALDH1A1DCTPP1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058565 | 0.87 | DCTPP1 (0.37) | ALDH1A1DCTPP1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058184 | 0.85 | ALDH1A1 (0.36) | ALDH1A1DCTPP1RXFP1SMN1; SMN2SLC2A1 | |
| SCHEMBL17058227 | 0.85 | SMN1; SMN2 (0.35) | ALDH1A1DCTPP1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058442 | 0.85 | DCTPP1 (0.39) | ALDH1A1DCTPP1RXFP1SMN1; SMN2SLC2A1 | |
| SCHEMBL17058454 | 0.85 | SMN1; SMN2 (0.35) | ALDH1A1DCTPP1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17057817 | 0.84 | SMN1; SMN2 (0.38) | ALDH1A1DCTPP1RXFP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |