Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058443 | 0.94 | DCTPP1 (0.37) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058220 | 0.89 | ALDH1A1 (0.39) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058227 | 0.88 | SMN1; SMN2 (0.35) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058454 | 0.88 | SMN1; SMN2 (0.35) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058442 | 0.88 | DCTPP1 (0.39) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058196 | 0.87 | ALDH1A1 (0.41) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17057988 | 0.86 | SMN1; SMN2 (0.39) | DCTPP1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL17058003 | 0.86 | SMN1; SMN2 (0.39) | DCTPP1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL17057817 | 0.85 | SMN1; SMN2 (0.38) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA | |
| SCHEMBL17058235 | 0.84 | DCTPP1 (0.36) | DCTPP1ALDH1A1RXFP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |