Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058545 | 0.91 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058392 | 0.81 | DCTPP1 (0.38) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17057986 | 0.81 | SMN1; SMN2 (0.38) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17057826 | 0.81 | SMN1; SMN2 (0.38) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058175 | 0.78 | MAPK14 (0.41) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17057899 | 0.77 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17057989 | 0.77 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058530 | 0.77 | MAPT (0.49) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL11943909 | 0.76 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058057 | 0.76 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |