Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058199 | 0.90 | MAPT (0.45) | MAPTLMNAPOLBALDH1A1MAPK1 | |
| SCHEMBL17057983 | 0.87 | MAPT (0.46) | MAPTLMNAPOLBALDH1A1MAPK1 | |
| SCHEMBL11943436 | 0.85 | SIGMAR1 (0.43) | MAPTLMNAPOLBALDH1A1MAPK1 | |
| SCHEMBL14081532 | 0.84 | LMNA (0.42) | MAPTLMNAPOLBALDH1A1MAPK1 | |
| SCHEMBL11943323 | 0.84 | ALDH1A1 (0.42) | MAPTLMNAPOLBALDH1A1MAPK1 | |
| SCHEMBL11943905 | 0.82 | ALDH1A1 (0.55) | MAPTLMNAPOLBALDH1A1HSD17B10 | |
| SCHEMBL11945023 | 0.81 | ALDH1A1 (0.54) | MAPTLMNAPOLBALDH1A1HSD17B10 | |
| SCHEMBL11943439 | 0.81 | MAPT (0.45) | MAPTLMNAPOLBALDH1A1MAPK1 | |
| SCHEMBL11943465 | 0.81 | SMN1; SMN2 (0.43) | MAPTLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL11943909 | 0.80 | ALDH1A1 (0.55) | MAPTLMNAPOLBALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |