Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058237 | 0.88 | SLC2A1 (0.33) | SLC2A1SLC2A3POLBCYP3A4CYP2C19 | |
| SCHEMBL17058519 | 0.86 | SLC2A1 (0.32) | SLC2A1SLC2A3POLBCYP3A4CYP2C19 | |
| SCHEMBL17058475 | 0.85 | — | — | |
| SCHEMBL17058248 | 0.85 | SLC2A1 (0.31) | SLC2A1SLC2A3 | |
| SCHEMBL17058242 | 0.84 | HTR1A (0.32) | — | |
| SCHEMBL11945888 | 0.84 | CYP3A4 (0.35) | SLC2A1SLC2A3POLBCYP3A4CYP2C19 | |
| SCHEMBL17058586 | 0.83 | SMN1; SMN2 (0.35) | SLC2A1SLC2A3POLBCYP3A4CYP2C19 | |
| SCHEMBL11945350 | 0.81 | MAPT (0.39) | SLC2A1SLC2A3POLBCYP3A4CYP2C19 | |
| SCHEMBL11945354 | 0.80 | CYP17A1 (0.39) | SLC2A1SLC2A3POLBCYP3A4CYP2C19 | |
| SCHEMBL17058289 | 0.79 | NPBWR1 (0.34) | SLC2A1SLC2A3POLBCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |