Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058517 | 0.90 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTALDH1A1DCTPP1RXFP1 | |
| SCHEMBL17058213 | 0.83 | LIN28A (0.33) | SMN1; SMN2MAPTALDH1A1DCTPP1RXFP1 | |
| SCHEMBL17058011 | 0.82 | SMN1; SMN2 (0.33) | SMN1; SMN2MAPTALDH1A1DCTPP1RXFP1 | |
| SCHEMBL11945969 | 0.81 | POLB (0.39) | SMN1; SMN2MAPTALDH1A1DCTPP1LMNA | |
| SCHEMBL17057840 | 0.77 | POLB (0.35) | SMN1; SMN2MAPTALDH1A1LMNAPOLB | |
| SCHEMBL17058526 | 0.76 | LIN28A (0.34) | SMN1; SMN2MAPTALDH1A1DCTPP1RXFP1 | |
| SCHEMBL17058459 | 0.73 | DCTPP1 (0.36) | SMN1; SMN2MAPTALDH1A1DCTPP1RXFP1 | |
| SCHEMBL17058587 | 0.73 | ALDH1A1 (0.31) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL17058247 | 0.73 | ALDH1A1 (0.34) | SMN1; SMN2MAPTALDH1A1DCTPP1RXFP1 | |
| SCHEMBL11945959 | 0.72 | MEN1 (0.34) | SMN1; SMN2MAPTALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |