LIN28A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3324591	0.60	2/20
SCHEMBL497135	0.58	2/20
SCHEMBL497311	0.48	2/20
SCHEMBL3882266	0.44	2/20
SCHEMBL3326999	0.42	2/20
SCHEMBL5147785	0.41	2/20
SCHEMBL3882238	0.39	2/20
SCHEMBL231092	1.00	1/20
SCHEMBL3475782	1.00	1/20
SCHEMBL6864020	0.85	1/20
SCHEMBL7107996	0.84	1/20
SCHEMBL138261	0.83	1/20
SCHEMBL343596	0.81	1/20
SCHEMBL5562538	0.81	1/20
SCHEMBL6864949	0.81	1/20
SCHEMBL2903674	0.79	1/20
SCHEMBL3626637	0.79	1/20
SCHEMBL6864610	0.79	1/20
SCHEMBL57060	0.78	1/20
SCHEMBL230051	0.78	1/20

Clinical trials — most relevant to LIN28A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Sclerosis (ALS)	PHASE2	COMPLETED
Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria	PHASE2	COMPLETED
Induced Pluripotent Stem Cell Derived Exosomes for the Treatment of Atopic Dermatitis	EARLY_PHASE1	UNKNOWN
Impact of IL-28B rs12979860 and rs4803217 Gene Polymorphisms Associated With miRNAs Deregulation on HCV-related Hepatocellular Carcinoma	nan	UNKNOWN
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases	nan	RECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes	nan	UNKNOWN
Impact of Weight Loss on the Human Sperm Epitranscriptome	nan	ACTIVE_NOT_RECRUITING
Genomic Imprinting Testing for Diagnosis of Bladder Cancer	nan	UNKNOWN
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes	nan	ACTIVE_NOT_RECRUITING
Lung Cancer Diagnosis by Detecting Epigenetic Imprinting Alterations in Bronchoalveolar Lavage	nan	UNKNOWN
Scottish Advanced Fetal Research Study	nan	RECRUITING
miR-155 Expression in Episodic and Chronic Migraine	nan	UNKNOWN
Role of Specific microRNAs in Cluster Headache	nan	RECRUITING
Maternal Hypertriglyceridaemia Study	nan	UNKNOWN
Search for Bovine miRNA Transference to Humans	nan	COMPLETED
The Relationship Between The Differential Expression Of FosB Protein In Laryngeal Cancer Tissues And Clinical Prognosis	nan	NOT_YET_RECRUITING
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Risk of HCC in Cirrhotic Patients Post DAAs Ttt	nan	UNKNOWN
Family Study of Head and Neck Cancers in Taiwan	nan	COMPLETED
MicroRNAs and Cytokines in Peri-Implantitis Tissue	nan	UNKNOWN
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Model to Predict pCR and IrAEs in Early Stage Non-small Cell Lung Cancer	nan	UNKNOWN
Role of Piwi-protein Interacting RNA, miRNA-194 and Amino Acids in Patients With Prostate Cancer	nan	UNKNOWN
Cytomegalovirus (CMV) MicroRNA Expression in Vivo and Immune Evasion Correlates	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Derivation of New Human Embryonic Stem Cell Lines: Identification of Instructive Factors for Germ Cells Development	nan	UNKNOWN
microRNA Profile in Early-stage Cervical Cancer	nan	COMPLETED
Research on Effects of Acute Consumption of Nuts in Obese Diabetic Women	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a LIN28A binder may also engage these)

Protein	Name	Similarity
Q8K3Y3	—	1.000	Q8K3Y3 →
Q45KJ5	—	0.990	Q45KJ5 →
Q45KJ6	—	0.983	Q45KJ6 →
Q6ZN17	—	0.981	Q6ZN17 →
Q803L0	—	0.978	Q803L0 →
Q45KJ4	—	0.973	Q45KJ4 →
Q8AVK2	—	0.967	Q8AVK2 →
Q5EB47	—	0.963	Q5EB47 →
Q8JHC4	—	0.950	Q8JHC4 →
Q99NA9	—	0.947	Q99NA9 →
Q5XI70	—	0.947	Q5XI70 →
Q3V038	—	0.943	Q3V038 →
PML	Protein PML	0.943	landscape →
Q96NA8	—	0.942	Q96NA8 →
A4Q9F4	—	0.942	A4Q9F4 →
Q5JSP0	—	0.941	Q5JSP0 →
Q8NHH1	—	0.941	Q8NHH1 →
Q8CE64	—	0.940	Q8CE64 →
Q80VL1	—	0.940	Q80VL1 →
Q9BYE7	—	0.939	Q9BYE7 →
Q9Y2W6	—	0.939	Q9Y2W6 →
O94888	—	0.938	O94888 →
Q92623	—	0.938	Q92623 →
Q5REY7	—	0.938	Q5REY7 →
Q5R5T1	—	0.938	Q5R5T1 →
Q8N554	—	0.937	Q8N554 →
METTL16	RNA N(6)-adenosine-methyltransferase METTL16	0.937	landscape →
Q9BT49	—	0.936	Q9BT49 →
Q922P9	—	0.936	Q922P9 →
Q6P9L4	—	0.936	Q6P9L4 →