Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933431 | 0.84 | ABL1 (0.48) | ABL1 | |
| SCHEMBL17899122 | 0.83 | PIK3CA (0.48) | PIK3CAPIK3R1MTORL3MBTL1ABL1 | |
| SCHEMBL896491 | 0.83 | PIK3CA (0.48) | PIK3CAPIK3R1MTORL3MBTL1HDAC4 | |
| SCHEMBL897009 | 0.81 | PIK3CA (0.50) | PIK3CAPIK3R1MTORL3MBTL1HDAC4 | |
| SCHEMBL8328931 | 0.79 | L3MBTL1 (0.59) | L3MBTL1ABL1PTK2NPC1RAB9A | |
| SCHEMBL20772436 | 0.78 | L3MBTL1 (0.53) | L3MBTL1ABL1PTK2NPC1RAB9A | |
| SCHEMBL21443101 | 0.76 | DYRK1A (0.40) | PIK3CAPIK3R1MTORABL1NPC1 | |
| SCHEMBL18809389 | 0.75 | PIK3R1 (0.33) | PIK3CAPIK3R1MTORABL1NPC1 | |
| SCHEMBL20861632 | 0.75 | L3MBTL1 (0.53) | L3MBTL1ABL1PTK2NPC1RAB9A | |
| SCHEMBL624251 | 0.75 | L3MBTL1 (0.53) | MTORL3MBTL1ABL1PTK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637468-B2 | Process for manufacturing 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine | NOVARTIS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| US-20150246897-A1 | Process for Manufacturing 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine | NOVARTIS PHARMA AG (CH) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246897-A1 | Process for Manufacturing 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine | PAH, QDPR, NISCH | PIK3CA 890/4885PIK3R1 3293/4885MTOR 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.