Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059588 | 0.81 | EGFR (0.61) | — | |
| SCHEMBL23065786 | 0.81 | KMT2A (0.62) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL22154745 | 0.81 | DDX3X (0.68) | DDX3XKMT2AMEN1POLBSMARCA2 | |
| SCHEMBL14447584 | 0.80 | ROCK1 (0.60) | CDK5KMT2AMEN1LMNAMAPT | |
| SCHEMBL17059595 | 0.80 | KMT2A (0.64) | DDX3XSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL12499946 | 0.79 | MEN1 (0.53) | SMN1; SMN2XBP1STAT3GSK3AGSK3B | |
| SCHEMBL17059658 | 0.78 | CSNK1A1 (0.58) | DDX3XSMN1; SMN2XBP1STAT3GSK3A | |
| SCHEMBL30314470 | 0.78 | DDX3X (1.00) | DDX3XSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL1657499 | 0.78 | DDX3X (1.00) | DDX3XSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL17059600 | 0.75 | EGFR (0.74) | DDX3XSMN1; SMN2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683168-B | Fragrant amino pyrimidines and its application and pharmaceutical composition prepared therefrom and Pharmaceutical composition | 上海海雁医药科技有限公司 | 2017-12-08 | — | — | CN | disclosed |
| CN-104860891-B | Fragrant amino pyrimidines and its application and pharmaceutical composition prepared therefrom and Pharmaceutical composition | 上海海雁医药科技有限公司 | 2017-06-30 | — | — | CN | disclosed |
| CN-105683168-A | Arylamino pyramidine compound and application thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom | 上海海雁医药科技有限公司 | 2016-06-15 | — | — | CN | disclosed |
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |