Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CPN1 | P15169 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30446809 | 0.90 | HRH1 (0.40) | KLKB1MAPTGFERCPN1CPB2 | |
| SCHEMBL17064662 | 0.90 | HRH1 (0.40) | KLKB1MAPTGFERCPN1CPB2 | |
| SCHEMBL17064512 | 0.86 | MEN1 (0.41) | MAPKAPK2SLC6A2SLC6A4SLC6A3PDE4A | |
| SCHEMBL30466449 | 0.86 | MEN1 (0.41) | MAPKAPK2SLC6A2SLC6A4SLC6A3PDE4A | |
| SCHEMBL17064729 | 0.80 | ALDH1A1 (0.44) | SLC6A2SLC6A4SLC6A3MAPTCYP3A4 | |
| SCHEMBL17073423 | 0.76 | CPN1 (0.41) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL31067489 | 0.76 | CPN1 (0.41) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL25667743 | 0.75 | CPN1 (0.36) | MAPKAPK2SLC6A2SLC6A4SLC6A3CPN1 | |
| SCHEMBL22417031 | 0.74 | KLKB1 (0.46) | MAPKAPK2KLKB1MAPT | |
| SCHEMBL17064513 | 0.71 | GRIN2B (0.35) | SLC6A2SLC6A4SLC6A3MAPTCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113772-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |