Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466449 | 1.00 | MEN1 (0.41) | MEN1PSIP1AXLMKNK1MKNK2 | |
| SCHEMBL17064585 | 0.86 | MAPKAPK2 (0.41) | SLC6A2SLC6A4SLC6A3MAPKAPK2PDE4A | |
| SCHEMBL30446809 | 0.84 | HRH1 (0.40) | MEN1LMNAPDE4A | |
| SCHEMBL17064662 | 0.84 | HRH1 (0.40) | MEN1LMNAPDE4A | |
| SCHEMBL17064553 | 0.83 | TBXAS1 (0.36) | TBXAS1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17064729 | 0.78 | ALDH1A1 (0.44) | MEN1SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL17073423 | 0.74 | CPN1 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31067489 | 0.74 | CPN1 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25667743 | 0.73 | CPN1 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2MAPKAPK2 | |
| SCHEMBL17064640 | 0.70 | SMN1; SMN2 (0.65) | MEN1PSIP1AXLMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113772-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |