Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14873325 | 0.94 | FFAR2 (0.47) | FFAR2TP53KDM4ECYP3A4LMNA | |
| SCHEMBL14862133 | 0.79 | FFAR2 (0.48) | FFAR2TP53KDM4ELMNASLC6A3 | |
| SCHEMBL8532540 | 0.79 | FFAR2 (0.48) | FFAR2TP53KDM4ELMNAALDH1A1 | |
| SCHEMBL5331611 | 0.78 | SLC6A2 (0.51) | FFAR2TP53KDM4ELMNATSHR | |
| SCHEMBL29207782 | 0.77 | FFAR2 (0.50) | FFAR2TP53KDM4ECYP3A4LMNA | |
| SCHEMBL21742332 | 0.76 | SLC6A3 (0.47) | FFAR2TP53KDM4ECYP3A4LMNA | |
| SCHEMBL20217621 | 0.76 | ALDH1A1 (0.46) | FFAR2TP53KDM4ESLC6A3CYP1A2 | |
| SCHEMBL30499277 | 0.76 | FFAR2 (0.44) | FFAR2TP53KDM4ELMNATSHR | |
| SCHEMBL14862646 | 0.75 | KDM4E (0.57) | FFAR2KDM4ECYP3A4LMNATSHR | |
| SCHEMBL20851460 | 0.73 | TSHR (0.47) | FFAR2TP53KDM4ECYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3355890-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3113772-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |