Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17065819 | 0.83 | KMT2A (0.47) | ATMMAPTTDP1SMN1; SMN2LMNA | |
| SCHEMBL17065824 | 0.82 | CALM1 (0.43) | NPC1RAB9AKMT2AMEN1TSHR | |
| SCHEMBL17065827 | 0.75 | PIM1 (0.40) | MAPTTDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL19212236 | 0.68 | NR1H2 (0.49) | ATMMAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17065826 | 0.68 | KDM4E (0.43) | MAPTSMN1; SMN2LMNAALDH1A1PIK3CD | |
| SCHEMBL21310342 | 0.66 | MAPT (0.45) | ATMMAPTTDP1SMN1; SMN2LMNA | |
| SCHEMBL6982805 | 0.66 | NR1H2 (0.58) | MAPTTDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL19862049 | 0.66 | SLC6A2 (0.42) | CYP1A2CYP2A6 | |
| SCHEMBL9809626 | 0.65 | MEN1 (0.48) | SMN1; SMN2ALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL21636847 | 0.65 | MAPT (0.44) | ATMMAPTTDP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113768-A1 | USE OF ARYLALKANOLAMINES AS SIGMA-1 RECEPTOR ANTAGONISTS | Universita' Degli Studi Di Pavia (IT) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015132733-A1 | USE OF ARYLALKANOLAMINES AS SIGMA-1 RECEPTOR ANTAGONISTS | UNIVERSITA' DEGLI STUDI DI PAVIA (IT) | 2015-09-11 | — | — | WO | disclosed |