Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17065826 | 0.81 | KDM4E (0.43) | PIM1SMN1; SMN2PDE5AALDH1A1KDM4E | |
| SCHEMBL17065819 | 0.76 | KMT2A (0.47) | PIM1SMN1; SMN2PDE5AALDH1A1KDM4E | |
| SCHEMBL17065825 | 0.75 | ATM (0.40) | PIM1SMN1; SMN2PDE5AALDH1A1KDM4E | |
| SCHEMBL17065824 | 0.68 | CALM1 (0.43) | NPC1RAB9ATSHRKMT2A | |
| SCHEMBL29732579 | 0.67 | HPRT1 (0.41) | ALDH1A1KDM4EHIF1ATSHRKMT2A | |
| SCHEMBL22721086 | 0.67 | HPRT1 (0.41) | ALDH1A1KDM4EHIF1ATSHRKMT2A | |
| SCHEMBL16875663 | 0.66 | ALDH1A1 (0.56) | ALDH1A1KDM4ENPC1RAB9AKMT2A | |
| SCHEMBL30966945 | 0.65 | SIGMAR1 (0.50) | PDE5AALDH1A1LMNATSHRKMT2A | |
| SCHEMBL2865598 | 0.65 | SIGMAR1 (0.50) | PDE5AALDH1A1LMNATSHRKMT2A | |
| SCHEMBL28795602 | 0.64 | POLB (0.48) | ALDH1A1KDM4EHIF1AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113768-A1 | USE OF ARYLALKANOLAMINES AS SIGMA-1 RECEPTOR ANTAGONISTS | Universita' Degli Studi Di Pavia (IT) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015132733-A1 | USE OF ARYLALKANOLAMINES AS SIGMA-1 RECEPTOR ANTAGONISTS | UNIVERSITA' DEGLI STUDI DI PAVIA (IT) | 2015-09-11 | — | — | WO | disclosed |