Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SHBG | P04278 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070650 | 0.86 | LMNA (0.30) | LMNACYP2C9 | |
| SCHEMBL20937109 | 0.86 | LMNA (0.37) | LMNACYP2C9 | |
| SCHEMBL23283026 | 0.83 | HRH3 (0.33) | HRH3 | |
| SCHEMBL22308026 | 0.80 | LMNA (0.33) | LMNACYP2C9 | |
| SCHEMBL10284003 | 0.79 | LMNA (0.36) | LMNACYP2C9 | |
| SCHEMBL19369446 | 0.77 | ACHE (0.34) | — | |
| SCHEMBL7696092 | 0.75 | LMNA (0.40) | LMNACYP2C9 | |
| SCHEMBL25084165 | 0.75 | LMNA (0.40) | LMNACYP2C9 | |
| SCHEMBL23365960 | 0.75 | LMNA (0.40) | LMNACYP2C9 | |
| SCHEMBL20970590 | 0.75 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026451-A1 | COMPOUNDS AND METHOD FOR TREATING CYTOKINE RELEASE SYNDROME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-02-11 | — | — | WO | disclosed |
| EP-2389372-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2015-09-09 | — | — | EP | disclosed |