Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17070960 | 0.86 | KMT2A (0.49) | KMT2APOLBALDH1A1PADI4FPR2 | |
| SCHEMBL21898615 | 0.84 | KMT2A (0.46) | KMT2APOLBALDH1A1PADI4FPR2 | |
| SCHEMBL16256882 | 0.78 | KMT2A (0.58) | KMT2APOLBALDH1A1PADI4FPR2 | |
| SCHEMBL11677768 | 0.75 | POLB (0.74) | KMT2APOLBALDH1A1PADI4MEN1 | |
| SCHEMBL14499599 | 0.74 | KMT2A (0.72) | KMT2APOLBALDH1A1FPR2MEN1 | |
| SCHEMBL8165986 | 0.71 | KMT2A (0.68) | KMT2APOLBALDH1A1PADI4MEN1 | |
| SCHEMBL6113379 | 0.71 | KMT2A (0.53) | KMT2APOLBALDH1A1PADI4FPR2 | |
| Methane SCHEMBL11598388 | 0.71 | POLB (0.61) | KMT2APOLBALDH1A1PADI4MEN1 | |
| SCHEMBL9787811 | 0.70 | POLB (0.65) | KMT2APOLBALDH1A1PADI4LMNA | |
| SCHEMBL13753309 | 0.70 | POLB (0.65) | KMT2APOLBALDH1A1PADI4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908853-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | THE HOSPITAL FOR SICK CHILDREN (CA) | 2018-03-06 | — | — | US | disclosed |
| US-20150252006-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | THE HOSPITAL FOR SICK CHILDREN (CA) | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252006-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | PADI2, PADI1, PADI4 | KMT2A 2452/4885POLB 3310/4885ALDH1A1 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.