Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MECP2 | P51608 | 3/20 | 1.00 |
| ▸ | MBD2 | Q9UBB5 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12692358 | 1.00 | MECP2 (1.00) | MECP2MBD2RAB9ANPC1MEN1 | |
| SCHEMBL6267593 | 0.72 | MECP2 (1.00) | MECP2MBD2RAB9ANPC1MEN1 | |
| SCHEMBL6274214 | 0.69 | RAB9A (0.52) | MECP2MBD2RAB9ANPC1MEN1 | |
| SCHEMBL15858577 | 0.68 | KDM4E (0.57) | MECP2MBD2RAB9AMEN1KMT2A | |
| SCHEMBL12443345 | 0.67 | MEN1 (0.64) | MECP2MBD2RAB9ANPC1MEN1 | |
| SCHEMBL11129658 | 0.66 | MECP2 (0.49) | MECP2MBD2MEN1KMT2APOLB | |
| SCHEMBL10655998 | 0.65 | CTH (0.59) | MECP2MBD2RAB9ANPC1MEN1 | |
| SCHEMBL9260279 | 0.63 | MECP2 (0.61) | MECP2MBD2RAB9ANPC1MEN1 | |
| SCHEMBL619730 | 0.62 | ESR1 (0.61) | POLBKDM4EMAPTALDH1A1GAA | |
| Ammonia Solution, Strong SCHEMBL10871253 | 0.60 | ESR1 (0.59) | POLBKDM4EMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150252438-A1 | AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES | THE JOHNS HOPKINS UNIVERSITY | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252438-A1 | AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES | MECP2, MBD2, GATAD2B | MECP2 1/4885MBD2 2/4885RAB9A 3374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.