Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.56 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11792553 | 0.76 | HDAC6 (0.48) | HDAC3HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL17072355 | 0.75 | NPC1 (0.55) | HDAC3NCOR1HCAR3MEN1LMNA | |
| SCHEMBL30834279 | 0.73 | RAB9A (0.73) | KMT2ANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3698385 | 0.70 | HDAC6 (1.00) | HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL18434189 | 0.68 | PDGFRB (0.53) | HCAR3MAPK8MAPK10MEN1LMNA | |
| SCHEMBL12723128 | 0.68 | HIF1A (0.61) | HDAC3HDAC6HDAC1HDAC8HDAC4 | |
| SCHEMBL71308 | 0.68 | HCAR3 (1.00) | HCAR3MEN1LMNAMAPTKMT2A | |
| SCHEMBL13187689 | 0.68 | HDAC6 (0.50) | HDAC3HDAC6MAPK8HDAC1HDAC8 | |
| SCHEMBL9076442 | 0.68 | HCAR3 (0.73) | HDAC6HCAR3HDAC8MEN1MAPT | |
| SCHEMBL19074726 | 0.67 | NPC1 (0.63) | LMNAMAPTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150250786-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250786-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | HDAC6, HDAC1, HDAC5 | HDAC3 5/4885NCOR1 949/4885HDAC6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.