Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10431529 | 0.81 | CES1 (0.67) | CES1CTBP2LMNARAB9ANPC1 | |
| SCHEMBL11389533 | 0.81 | HPGD (0.55) | CES1HPGDCTBP2KMT2ASMN1; SMN2 | |
| SCHEMBL28264746 | 0.79 | CES1 (0.64) | CES1FAAHCA2 | |
| SCHEMBL8799245 | 0.79 | CES1 (0.64) | CES1HPGDCTBP2KMT2ASMN1; SMN2 | |
| SCHEMBL28268026 | 0.79 | CES1 (0.64) | CES1HPGDKMT2ASMN1; SMN2GAA | |
| SCHEMBL17210682 | 0.79 | CES1 (0.58) | CES1CTBP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1042453 | 0.78 | CES1 (1.00) | CES1KMT2AMEN1FAAH | |
| SCHEMBL5709778 | 0.78 | CES1 (1.00) | CES1KMT2AMEN1FAAH | |
| SCHEMBL28708887 | 0.77 | CES1 (0.61) | CES1CTBP2L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL583920 | 0.76 | CES1 (0.78) | CES1HPGDKMT2AGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192733-A1 | SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE | 2023-06-22 | — | — | US | disclosed |
| CN-109608323-B | Beta-trifluoromethyl-beta-hydroxy substituted cyclohexanone derivative and synthesis method thereof | 华南理工大学 | 2021-07-20 | — | — | CN | disclosed |
| CN-111886283-A | Chemical process for the preparation of covalent adaptive networks | 罗伯特·博世有限公司 | 2020-11-03 | — | — | CN | disclosed |
| US-9771369-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771369-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-20150284397-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2015-10-08 | — | — | US | disclosed |
| US-20150284397-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2015-10-08 | — | — | US | disclosed |
| WO-2015134536-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2015-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192733-A1 | SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SARS1, ACE2, ACE | CES1 930/4885HPGD 3870/4885CTBP2 2316/4885 |
| US-20150284397-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | KIT, PRKCH, PRKACA | CES1 2422/4885HPGD 2520/4885CTBP2 2300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.