SCHEMBL1707366

SCHEMBL1707366

CSc1nc(NC(=O)NC(=O)[C@@H](N)[C@@H](C)O)c2ncn([C@@H]3O[C@H](CO)C(O)C3O)c2n1

nearest known ligand 0.60

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.51
ADORA1 P30542 1/20 0.51
KDM4E B2RXH2 1/20 0.50
PKM P14618 1/20 0.50
CYP2C19 P33261 1/20 0.49
SLC29A1 Q99808 2/20 0.47
PGK1 P00558 1/20 0.47
PGK2 P07205 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1274810 1.00 ADORA3 (0.51) ADORA3ADORA1KDM4EPKMCYP2C19
SCHEMBL1274809 1.00 ADORA3 (0.51) ADORA3ADORA1KDM4EPKMCYP2C19
SCHEMBL29389281 1.00 ADORA3 (0.51) ADORA3ADORA1KDM4EPKMCYP2C19
SCHEMBL28894185 0.93 ADORA3 (0.54) ADORA3ADORA1KDM4EPKMCYP2C19
SCHEMBL28894183 0.93 ADORA3 (0.54) ADORA3ADORA1KDM4EPKMCYP2C19
SCHEMBL17984828 0.90 ADORA2A (0.47)
SCHEMBL28671616 0.89 ADORA3 (0.52) ADORA3ADORA1KDM4EPKMCYP2C19
SCHEMBL28671612 0.89 ADORA3 (0.52) ADORA3ADORA1KDM4EPKMCYP2C19
SCHEMBL63913 0.86 KDM4E (0.51) ADORA3ADORA1KDM4EPKM
SCHEMBL63914 0.86 KDM4E (0.51) ADORA3ADORA1KDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1092 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250382669-A1 METHOD FOR ANALYZING MODIFIED NUCLEOSIDE SHIMADZU CORPORATION (JP) 2025-12-18 US claimed
US-20250325494-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-10-23 US claimed
EP-4634380-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-10-22 EP claimed
US-20250188013-A1 LIPID COMPOUND AND USE THEREOF THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-06-12 US claimed
EP-4565692-A2 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-06-11 EP claimed
EP-4008334-B1 MANNOSE-BASED MRNA TARGETED DELIVERY SYSTEM AND USE THEREOF SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD (CN) 2024-12-04 EP claimed
US-20240285795-A1 TARGETS FOR RNA THERAPEUTICS CureVac SE (DE) 2024-08-29 US claimed
EP-4393484-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID Themedium Therapeutics Co., Ltd. (CN) 2024-07-03 EP claimed
EP-4393511-A1 LIPID COMPOUND AND USE THEREOF Themedium Therapeutics Co., Ltd. (CN) 2024-07-03 EP claimed
WO-2024129779-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION MODERNATX, INC. (US) 2024-06-20 WO claimed
WO-2024012272-A1 LIPID COMPOUND AND USE THEREOF 传信生物医药(苏州)有限公司 2024-01-18 WO claimed
WO-2023215498-A2 COMPOSITIONS AND METHODS FOR CD28 ANTAGONISM MODERNATX, INC. (US) 2023-11-09 WO claimed
US-11707528-B2 Mannose-based mRNA targeted delivery system and use thereof SHENZHEN RHEGEN BIOTECHNOLOGY CO., LTD. (CN) 2023-07-25 US claimed
EP-4008334-A1 MANNOSE-BASED MRNA TARGETED DELIVERY SYSTEM AND USE THEREOF Shenzhen Rhegen Biomedical Technology Co., Ltd. (CN) 2022-06-08 EP claimed
US-20220118099-A1 Mannose-Based mRNA Targeted Delivery System and Use Thereof SHENZHEN RHEGEN BIOTECHNOLOGY CO., LTD. (CN) 2022-04-21 US claimed
WO-2022000884-A1 MANNOSE-BASED MRNA TARGETED DELIVERY SYSTEM AND USE THEREOF 深圳市瑞吉生物科技有限公司 2022-01-06 WO claimed
US-20180126003-A1 NEW TARGETS FOR RNA THERAPEUTICS CureVac SE (DE) 2018-05-10 US claimed
EP-2201118-B1 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION TRANA DISCOVERY (US) 2012-04-18 EP claimed
EP-2201118-A2 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION Trana Discovery (US) 2010-06-30 EP claimed
WO-2009036299-A2 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION TRANA DISCOVERY (US) 2009-03-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250325494-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID FABP1, POLRMT, LIPC ADORA3 2239/4885ADORA1 2553/4885KDM4E 4795/4885
US-20250188013-A1 LIPID COMPOUND AND USE THEREOF NPC1L1, CYP46A1, PCSK9 ADORA3 3881/4885ADORA1 3765/4885KDM4E 3530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.