Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561000 | 0.90 | LTA4H (0.50) | KDM4ETSHRKDRHTR2CHTR2B | |
| SCHEMBL31068420 | 0.87 | POLB (0.51) | KDM4EPOLBTSHRSYKALDH1A1 | |
| SCHEMBL722986 | 0.86 | SYK (0.50) | KDM4EPOLBTSHRSYKHTR2C | |
| SCHEMBL13957871 | 0.86 | POLB (0.44) | KDM4EPOLBTSHRSYKHTR2C | |
| SCHEMBL14758443 | 0.84 | TSHR (0.62) | KDM4EPOLBTSHRHTR2CHTR2B | |
| SCHEMBL430271 | 0.84 | ALDH1A1 (0.43) | POLBTSHRSYKALDH1A1MAPT | |
| SCHEMBL22636056 | 0.82 | ALDH1A1 (0.44) | POLBTSHRSYKHTR2CHTR2B | |
| SCHEMBL2801570 | 0.82 | KDM4E (0.45) | KDM4EPOLBTSHRHTR2BALDH1A1 | |
| SCHEMBL2797649 | 0.81 | TSHR (0.52) | KDM4ETSHRSYKHTR2BALDH1A1 | |
| SCHEMBL171775 | 0.81 | ALDH1A1 (0.55) | KDM4ETSHRHTR2BLTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3053923-B1 | TRIAZOLOPYRAZINE DERIVATIVES AS TYROSIN KINASE INHIBITORS | KOREA RES INST CHEMICAL TECH (KR) | 2018-04-11 | — | — | EP | disclosed |
| EP-3053923-A1 | NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF | Korea Research Institute of Chemical Technology (KR) | 2016-08-10 | — | — | EP | disclosed |
| US-9403831-B2 | Triazolopyrazine derivative and use thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2016-08-02 | — | — | US | disclosed |
| US-20150259350-A1 | NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF | HANDOK INC. (KR) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259350-A1 | NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF | MET, RET, BRAF | KDM4E 1039/4885POLB 3908/4885TSHR 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.