Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.48 |
| ▸ | THRA | P10827 | 8/20 | 0.38 |
| ▸ | THRB | P10828 | 8/20 | 0.38 |
| ▸ | CES2 | O00748 | 4/20 | 0.37 |
| ▸ | CES1 | P23141 | 4/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791412 | 1.00 | DNM1 (0.48) | DNM1THRATHRBCES2CES1 | |
| SCHEMBL21698552 | 0.93 | DNM1 (0.44) | DNM1THRATHRBCES2CES1 | |
| SCHEMBL19034541 | 0.83 | DNM1 (0.36) | DNM1THRATHRBALDH1A1TSHR | |
| SCHEMBL506355 | 0.83 | CES2 (0.50) | THRBCES2CES1AKR1B1ALDH1A1 | |
| SCHEMBL27383432 | 0.80 | KDM4C (0.50) | DNM1 | |
| SCHEMBL20854575 | 0.80 | CES2 (0.52) | THRBCES2CES1ALDH1A1TSHR | |
| SCHEMBL20854574 | 0.80 | CES2 (0.52) | THRBCES2CES1ALDH1A1TSHR | |
| SCHEMBL20854578 | 0.80 | CES2 (0.52) | THRBCES2CES1ALDH1A1TSHR | |
| SCHEMBL20774476 | 0.80 | CES2 (0.52) | THRBCES2CES1ALDH1A1TSHR | |
| SCHEMBL20854579 | 0.80 | CES2 (0.52) | THRBCES2CES1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791300-B2 | Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis | GRUENENTHAL GMBH (DE) | 2014-07-29 | — | — | US | claimed |
| EP-1943211-B1 | PROCESS FOR PREPARING SUBSTITUTED DIMETHYL(3-ARYLBUTYL)AMINE COMPOUNDS BY MEANS OF HOMOGENEOUS CATALYSIS | GRUENENTHAL GMBH (DE) | 2011-08-17 | — | — | EP | claimed |
| EP-1636169-B1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | GRUENENTHAL GMBH (DE) | 2010-06-02 | — | — | EP | claimed |
| US-20090043132-A1 | Process for Preparing a Substituted Dimethyl-(3-arylbutyl)amine Compound by Homogeneous Catalysis | GRUENENTHAL GMBH (DE) | 2009-02-12 | — | — | US | claimed |
| EP-1636169-A1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2006-03-22 | — | — | EP | claimed |
| US-20050176790-A1 | Pharmaceutical salts | GRUNENTHAL GMBH (DE) | 2005-08-11 | — | — | US | claimed |
| WO-2005000788-A1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2005-01-06 | — | — | WO | claimed |
| EP-0983995-B1 | Pharmaceutically-active dimethyl-(3-aryl-but-3-enyl)-amine compounds | GRUENENTHAL GMBH (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1069106-B1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-5811582-A | ANALGESICS | GRUENENTHAL GMBH (DE) | 1998-09-22 | — | — | US | claimed |
| US-10160719-B2 | Pharmaceutical salts | GRUNENTHAL GMBH (DE) | 2018-12-25 | — | — | US | disclosed |
| US-20170137370-A1 | PHARMACEUTICAL SALTS | Grünenthal GmbH (DE) | 2017-05-18 | — | — | US | disclosed |
| US-20150183727-A1 | METHOD FOR THE PREPARATION OF 1-ARYL-1-ALKYL-2-ALKYL-3-DIALKYLAMINOPROPANE COMPOUNDS | SIEGFRIED AG (CH) | 2015-07-02 | — | — | US | disclosed |
| US-8791300-B2 | Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis | GRUENENTHAL GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8704002-B2 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)-amine compounds by heterogeneous catalysis | Grünenthal GmbH (DE) | 2014-04-22 | — | — | US | disclosed |
| CN-1163884-A | Dimethyl-(3-aryl-but-3-enyl)-amine compounds as pharmaceutical active ingredients | GRUENENTHAL GMBH (DE) | 1997-11-05 | — | — | CN | disclosed |
| CN-1163884-A | Dimethyl-(3-aryl-but-3-enyl)-amine compounds as pharmaceutical active ingredients | GRUENENTHAL GMBH (DE) | 1997-11-05 | — | — | CN | disclosed |
| EP-0799819-A1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |
| EP-0799819-A1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |
| EP-0799819-A1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176790-A1 | Pharmaceutical salts | SLC5A1, SLC5A2, SLC35A1 | DNM1 1728/4885THRA 3114/4885THRB 4301/4885 |
| US-10160719-B2 | Pharmaceutical salts | SLC5A1, SLC5A2, SLC35A1 | DNM1 1999/4885THRA 3394/4885THRB 4373/4885 |
| US-20150183727-A1 | METHOD FOR THE PREPARATION OF 1-ARYL-1-ALKYL-2-ALKYL-3-DIALKYLAMINOPROPANE COMPOUNDS | CYP3A43, CYP1A2, CYP2C8 | DNM1 3548/4885THRA 2822/4885THRB 3370/4885 |
| US-20170137370-A1 | PHARMACEUTICAL SALTS | SLC5A1, SLC5A2, SLC35A1 | DNM1 1999/4885THRA 3394/4885THRB 4373/4885 |
| US-20090043132-A1 | Process for Preparing a Substituted Dimethyl-(3-arylbutyl)amine Compound by Homogeneous Catalysis | HRH3, CAT, CMA1 | DNM1 1391/4885THRA 1591/4885THRB 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.